Journal article
The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.
- Abstract:
-
A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) asso...
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- Publication status:
- Published
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- Publisher copy:
- 10.1158/0008-5472.can-14-1531
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Authors
Bibliographic Details
- Publisher:
- American Association for Cancer Research Inc.
- Journal:
- Cancer research
- Volume:
- 74
- Issue:
- 20
- Pages:
- 5808-5818
- Publication date:
- 2014-10-01
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
486980
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:486980
- UUID:
-
uuid:f2320d2d-f371-4b24-814c-a62376e174d3
- Local pid:
- pubs:486980
- Deposit date:
- 2014-10-23
Terms of use
- Copyright date:
- 2014
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