A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) asso...Expand abstract
- Publication status:
- Publisher copy:
- American Association for Cancer Research Inc.
- Cancer research
- Publication date:
- Source identifiers:
- Local pid:
- Copyright date:
The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.
If you are the owner of this record, you can report an update to it here: Report update to this record