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The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.

Abstract:

A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) asso...

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Publication status:
Published

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Authors


Figueroa, JD More by this author
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Publisher:
American Association for Cancer Research Inc.
Journal:
Cancer research
Volume:
74
Issue:
20
Pages:
5808-5818
Publication date:
2014-10-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:f2320d2d-f371-4b24-814c-a62376e174d3
Source identifiers:
486980
Local pid:
pubs:486980

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