The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.

Fu, YP; Kohaar, I; Moore, LE; Lenz, P; Figueroa, JD; Tang, W; Porter-Gill, P; Chatterjee, N; Scott-Johnson, A; Garcia-Closas, M; Muchmore, B; Baris, D; Paquin, A; Ylaya, K; Schwenn, M; Apolo, AB; Karagas, MR; Tarway, M; Johnson, A; Mumy, A; Schned, A; Guedez, L; Jones, MA; Kida, M; Hosain, GM; Malats, N; Kogevinas, M; Tardon, A; Serra, C; Carrato, A; Garcia-Closas, R; Lloreta, J; Wu, X; Purdue, M; Andriole, GL; Grubb, RL; Black, A; Landi, MT; Caporaso, NE; Vineis, P; Siddiq, A; Bueno-de-Mesquita, HB; Trichopoulos, D; Ljungberg, B; Severi, G; Weiderpass, E; Krogh, V; Dorronsoro, M; Travis, RC; Tjønneland, A; Brennan, P; Chang-Claude, J; Riboli, E; Prescott, J; Chen, C; De Vivo, I; Govannucci, E; Hunter, D; Kraft, P; Lindstrom, S; Gapstur, SM; Jacobs, EJ; Diver, WR; Albanes, D; Weinstein, SJ; Virtamo, J; Kooperberg, C; Hohensee, C; Rodabough, RJ; Cortessis, VK; Conti, DV; Gago-Dominguez, M; Stern, MC; Pike, MC; Van Den Berg, D; Yuan, JM; Haiman, CA; Cussenot, O; Cancel-Tassin, G; Roupret, M; Comperat, E; Porru, S; Carta, A; Pavanello, S; Arici, C; Mastrangelo, G; Grossman, HB; Wang, Z; Deng, X; Chung, CC; Hutchinson, A; Burdette, L; Wheeler, W; Fraumeni, J; Chanock, SJ; Hewitt, SM; Silverman, DT; Rothman, N; Prokunina-Olsson, L

Abstract:

A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) asso...

Expand abstract

Publication status:

Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Fu, Y. P., Kohaar, I., Moore, L. E., Lenz, P., Figueroa, J. D., Tang, W., Porter-Gill, P., Chatterjee, N., Scott-Johnson, A., Garcia-Closas, M., Muchmore, B., Baris, D., Paquin, A., Ylaya, K., Schwenn, M., Apolo, A. B., Karagas, M. R., Tarway, M., Johnson, A., … Prokunina-Olsson, L. (2014). The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. Cancer Research, 74(20), 5808–5818.

MLA Style

Fu, Y. P., et al. “The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease.” Cancer Research, vol. 74, no. 20, Cancer research, 2014, pp. 5808–18.

Chicago Style

Fu, YP, I Kohaar, LE Moore, P Lenz, JD Figueroa, W Tang, P Porter-Gill, et al. 2014. “The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease.” Cancer Research 74 (20): 5808–18.
Tweet
Print