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Condensation of the plasma membrane at the site of T lymphocyte activation.

Abstract:

After activation, T lymphocytes restructure their cell surface to form membrane domains at T cell receptor (TCR)-signaling foci and immunological synapses (ISs). To address whether these rearrangements involve alteration in the structure of the plasma membrane bilayer, we used the fluorescent probe Laurdan to visualize its lipid order. We observed a condensation of the plasma membrane at TCR activation sites. The formation of ordered domains depends on the presence of the transmembrane protei...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.200505047

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of cell biology
Volume:
171
Issue:
1
Pages:
121-131
Publication date:
2005-10-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:f2311910-d295-4c09-af98-9c5d6e35586e
Source identifiers:
6838
Local pid:
pubs:6838

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