Atherogenic dyslipidemia and altered hepatic gene expression in SHRSP.Z-Leprfa/IzmDmcr rats.

Journal article

We investigated lipid and lipoprotein abnormalities in SHRSP fatty rats as a new animal model of metabolic syndrome. We examined differentially expressed genes in the liver, one of the major tissues contributing to lipid metabolism. Using gel filtration high performance liquid chromatography, increased cholesterol concentrations of small particle size low-density lipoprotein (LDL) fractions were observed in SHRSP fatty rats, whereas the Zucker Fatty strain did not show a similar elevation of ...

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Authors: Ueno, T; Fukuda, N; Nagase, H; Tsunemi, A; Tahira, K

• Publication status: Published
• Journal: International journal of molecular medicine
• Volume: 23
• Issue: 3
• Pages: 313-320
• Publication date: 2009-03-01
• DOI: 10.3892/ijmm_00000133
• EISSN: 1791-244X
• ISSN: 1107-3756
• Language: English
• Keywords: Apolipoproteins B; Species Specificity; Rats, Inbred WKY; Gene Expression Regulation; Animals; Liver; Rats, Inbred SHR; Lipid Metabolism; Cholesterol, LDL; Dyslipidemias; Rats, Zucker; Rats; Metabolic Syndrome X