- Abstract:
-
Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) enhances tumor cell sensitivity to ionizing radiation. It is not clear how this effect is mediated, nor whether this approach can be applied effectively in the clinic. We previously showed that IGF-1R depletion delays repair of radiation-induced DNA double-strand breaks (DSBs), unlikely to be explained entirely by reduction in homologous recombination (HR) repair. The current study tested the hypothesis that IGF-1R inhibition i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/onc.2013.460
-
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- Journal:
- Oncogene
- Volume:
- 33
- Issue:
- 45
- Pages:
- 5262-5273
- Publication date:
- 2014-11-05
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- URN:
-
uuid:f22b4dd6-a235-4b7b-a342-aad03d15f995
- Source identifiers:
-
434126
- Local pid:
- pubs:434126
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
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