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Analysis of B cell selection mechanisms in the adaptive immune response

Abstract:

The essential task of a germinal centre reaction is the selection of those B cells that bind the antigen with high affinity. The exact mechanisms of B cell selection is still unknown and rather difficult to be accessed in experiment. With the help of an already established agent-based model for the space-time-dynamics of germinal centre reactions [1,2] we compare the most important hypotheses for what the limiting factor for B cell rescue may be. We discuss competition for antigen sites on...

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M. E. Meyer-Hermann More by this author
P. K. Maini More by this author
Publication date:
2005
URN:
uuid:f227607c-862f-45f4-8716-899ccb0a2193
Local pid:
oai:eprints.maths.ox.ac.uk:720

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