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Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor.

Abstract:

The monoclonal antibody hGR-2 F6 has been raised against the human glucagon receptor and shown to act as a competitive antagonist. As a first step in the structural characterization of the receptor, the crystal structure of the Fab fragment from this antibody is reported at 2.1 A resolution. The hGR-2 F6 Fab crystallizes in the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 76.14, b = 133.74, c = 37.46 A. A model generated by homology modelling was used as an aid in the ch...

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Publication status:
Published

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Publisher copy:
10.1107/s090744490000233x

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Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
56
Issue:
Pt 5
Pages:
573-580
Publication date:
2000-05-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:f21df8d8-2173-4f6d-b6cb-0edbf6bcffe9
Source identifiers:
317557
Local pid:
pubs:317557

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