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Morphological effects of G-quadruplex stabilization using a small molecule in zebrafish.

Abstract:

Zebrafish (Danio rerio) embryos are transparent and advantageous for studying early developmental changes due to ex utero development, making them an appropriate model for studying gene expression changes as a result of molecular targeting. Zebrafish embryos were injected with a previously reported G-quadruplex selective ligand, and the phenotypic changes were recorded. We report marked discrepancies in the development of intersegmental vessels. In silico analysis determined that the putative...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/bi4009352

Authors


Agarwal, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Chakraborty, TK More by this author
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Department of Science and Technology, Ministry of Science and Technology More from this funder
Publisher:
ACS Publications Publisher's website
Journal:
Biochemistry Journal website
Volume:
53
Issue:
7
Pages:
1117-1124
Publication date:
2014-02-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:f21d5bf4-af7d-42e3-82f6-7bb31db3ec77
Source identifiers:
472431
Local pid:
pubs:472431

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