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Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.

Abstract:

The XMAP215/ch-TOG/Msps family of microtubule-associated proteins (MAPs) promote microtubule growth in vitro and are concentrated at centrosomes in vivo. We show here that Msps (mini-spindles protein) interacts with the centrosomal protein D-TACC, and that this interaction strongly influences microtubule behaviour in Drosophila embryos. If D-TACC levels are reduced, Msps does not concentrate at the centrosomes efficiently and the centrosomal microtubules appear to be destabilized. If D-TACC l...

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Publication status:
Published

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Publisher copy:
10.1038/35083033

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Journal:
Nature cell biology
Volume:
3
Issue:
7
Pages:
643-649
Publication date:
2001-07-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:f20b4cb5-b089-4599-8cf8-757e37e1807e
Source identifiers:
223372
Local pid:
pubs:223372

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