Development of the Korea-Polyenvironmental Risk Score for Psychosis

Jeon, E-J; Kang, S-H; Piao, Y-H; Kim, S-W; Kim, J-J; Lee, B-J; Yu, J-C; Lee, K-Y; Won, S-H; Lee, S-H; Kim, S-H; Kim, E-T; Kim, CT; Oliver, D; Fusar-Poli, P; Rami, FZ; Chung, Y-C

Journal article

Development of the Korea-Polyenvironmental Risk Score for Psychosis

Abstract:: Objective: Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs). Methods: We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for Western studies and the "population proportion" (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS). Results: We first constructed the "K-PERS-I," comprising five factors based on the PPS, and then the "K-PERS-II" comprising six factors based on the ERS. The instruments accurately predicted participants' status (case vs. control). In addition, the K-PERS-I and -II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS. Conclusion: The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Jeon, E.-J., Kang, S.-H., Piao, Y.-H., Kim, S.-W., Kim, J.-J., Lee, B.-J., Yu, J.-C., Lee, K.-Y., Won, S.-H., Lee, S.-H., Kim, S.-H., Kim, E.-T., Kim, C. T., Oliver, D., Fusar-Poli, P., Rami, F. Z., & Chung, Y.-C. (2022). Development of the Korea-Polyenvironmental Risk Score for Psychosis. Psychiatry Investigation, 19(3), 197–206.

MLA Style

Jeon, E-J, et al. “Development of the Korea-Polyenvironmental Risk Score for Psychosis.” Psychiatry Investigation, vol. 19, no. 3, 2022, pp. 197–206.

Chicago Style

Jeon, E-J, S-H Kang, Y-H Piao, et al. 2022. “Development of the Korea-Polyenvironmental Risk Score for Psychosis.” Psychiatry Investigation 19 (3): 197–206.
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