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Journal article

The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man.

Abstract:

1. Opioid drugs act on specific receptors which are principally classified into mu, delta and kappa subtypes. Spiradoline (U-62066E) is a kappa-selective agent which has been shown to possess potent anti-nociceptive effects but does not show cross tolerance with morphine. 2. We have assessed the neuroendocrine effects of spiradoline in healthy volunteers with two doses (1.6 and 4.0 micrograms kg-1, i.m.) of the compound. Six male non-smokers aged 19-27 years were studied by use of a randomize...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0700971

Authors


Wright, DM More by this author
Bouloux, PM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
British journal of pharmacology
Volume:
120
Issue:
5
Pages:
781-784
Publication date:
1997-03-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:f1fb8c90-d144-4cfc-97b5-08833d0018c0
Source identifiers:
138541
Local pid:
pubs:138541

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