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Drug binding revealed by tandem mass spectrometry of a protein-micelle complex.

Abstract:

The protein-micelle complex formed between the protein EmrE and the lipid dodecylmaltoside has been examined by mass spectrometry. The results show that despite the unfavorable hydrophobic environment in the mass spectrometer it is possible to preserve protein submicelle complexes in the gas phase. The peaks assigned to the submicelle complexes are broad in nature and consistent with a heterogeneous distribution of lipid molecules attached to the protein complex. As such, the spectrum cannot ...

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Publication status:
Published

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Publisher copy:
10.1021/ja0450307
Journal:
Journal of the American Chemical Society More from this journal
Volume:
126
Issue:
44
Pages:
14362-14363
Publication date:
2004-11-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Keywords:
Pubs id:
pubs:59267
UUID:
uuid:f1fb1431-1df8-41de-b114-715b7dbdde51
Local pid:
pubs:59267
Source identifiers:
59267
Deposit date:
2012-12-19

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