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Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting. - A multicenter phase I and safety study -.

Abstract:

BACKGROUND: Increasing numbers of patients with advanced coronary artery disease have limited options for percutaneous and/or surgical revascularization. A prospective, randomized, phase I clinical multicenter trial was performed to assess the feasibility and safety of delivering a pro-angiogenic transcription factor termed "hypoxia inducible factor-1alpha", delivered to ischemic cardiac muscle via a type 2 adenoviral (Ad2HIF) vector. METHODS AND RESULTS: The 13 patients were included under ...

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Publication status:
Published

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Publisher copy:
10.1253/circj.cj-09-0594

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Journal:
Circulation journal : official journal of the Japanese Circulation Society More from this journal
Volume:
74
Issue:
5
Pages:
916-924
Publication date:
2010-05-01
DOI:
EISSN:
1347-4820
ISSN:
1346-9843
Language:
English
Keywords:
Pubs id:
pubs:104804
UUID:
uuid:f1f9e20d-59b2-489d-ae22-739892c0d9a0
Local pid:
pubs:104804
Source identifiers:
104804
Deposit date:
2012-12-19

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