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Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

Abstract:

Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We report the identification of a genetic interval Hiccs that regulates Helicobacter hepaticus-induced colitis and associated ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20120239

Authors


Boulard, O More by this author
Kirchberger, S More by this author
Royston, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
The Journal of experimental medicine
Volume:
209
Issue:
7
Pages:
1309-1324
Publication date:
2012-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:f1f6503a-616e-4464-b2d1-79752d160ff3
Source identifiers:
341064
Local pid:
pubs:341064

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