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Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

Abstract:

Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We report the identification of a genetic interval Hiccs that regulates Helicobacter hepaticus-induced colitis and associated ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20120239

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
209
Issue:
7
Pages:
1309-1324
Publication date:
2012-07-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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