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Protochordate Zic genes define primitive somite compartments and highlight molecular changes underlying neural crest evolution.

Abstract:

The vertebrate Zic gene family encodes C2H2 zinc finger transcription factors closely related to the Gli proteins. Zic genes are expressed in multiple areas of developing vertebrate embryos, including the dorsal neural tube where they act as potent neural crest inducers. Here we describe the characterization of a Zic ortholog from the amphioxus Branchiostoma floridae and further describe the expression of a Zic ortholog from the ascidian Ciona intestinalis. Molecular phylogenetic analysis and...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Evolution and development
Volume:
5
Issue:
2
Pages:
136-144
Publication date:
2003-01-01
DOI:
EISSN:
1525-142X
ISSN:
1520-541X
URN:
uuid:f1f2d39f-33ba-4cb6-9b51-14a10ed59040
Source identifiers:
209908
Local pid:
pubs:209908

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