Genomic imbalances are confined to non-proliferating cells in paediatric patients with acute myeloid leukaemia and a normal or incomplete karyotype.

Journal article

Leukaemia is often associated with genetic alterations such as translocations, amplifications and deletions, and recurrent chromosome abnormalities are used as markers of diagnostic and prognostic relevance. However, a proportion of acute myeloid leukaemia (AML) cases have an apparently normal karyotype despite comprehensive cytogenetic analysis. Based on conventional cytogenetic analysis of banded chromosomes, we selected a series of 23 paediatric patients with acute myeloid leukaemia and pe...

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Authors: Ballabio, E; Regan, R; Garimberti, E; Harbott, J; Bradtke, J

• Publication status: Published
• Journal: PloS one
• Volume: 6
• Issue: 6
• Pages: e20607
• Publication date: 2011-01-01
• DOI: 10.1371/journal.pone.0020607
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Cell Proliferation; DNA Copy Number Variations; Genome, Human; Male; Cell Nucleus; Child; Humans; Female; Karyotyping; Fluorescent Antibody Technique; Comparative Genomic Hybridization; Adult; Reproducibility of Results; In Situ Hybridization, Fluorescence; Chromosome Aberrations; Leukemia, Myeloid, Acute; Infant