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P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.

Abstract:

PURPOSE: Diabetes can impact on cardiovascular health by causing a distinct condition termed "diabetic cardiomyopathy". Its characteristic left ventricular (LV) diastolic dysfunction has been associated with interstitial fibrosis, reduced NO availability, and abnormal calcium handling. However, the early triggers and the underlying cellular mechanisms remain unknown. Here, we investigate changes in vascular and myocardial reactive oxygen species (ROS) and NO availability in a murine model of ...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvu098.107

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Journal:
Cardiovascular research More from this journal
Volume:
103 Suppl 1
Issue:
suppl 1
Pages:
S125
Publication date:
2014-07-01
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Language:
English
Pubs id:
pubs:475910
UUID:
uuid:f1e3e3a7-59e7-495f-850a-8a78a4402eb7
Local pid:
pubs:475910
Source identifiers:
475910
Deposit date:
2014-08-22

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