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Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis

Abstract:

Background: The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying amino acid sites that distinguish specific sets of protein sequences, by comparative analysis of matched alignments. The use of mutual information to identify distinctive residues responsible for functional variants makes this approach highly suitable for analyzing large sets ...

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Publisher copy:
10.1186/1471-2105-9-S1-S18

Authors


Journal:
Asia Pacific Bioinformatics Network (APBioNet) 6th International Conference on Bioinformatics, InCoB 2007 - Proceedings
Volume:
9
Issue:
SUPPL. 1
Publication date:
2007-01-01
DOI:
URN:
uuid:f1e08d92-2a10-4fc4-9612-335d3403b30e
Source identifiers:
377382
Local pid:
pubs:377382
Language:
English

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