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Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.

Abstract:
Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4269/ajtmh.13-0706

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author


Publisher:
American Journal of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene More from this journal
Volume:
90
Issue:
4
Pages:
609-611
Publication date:
2014-04-01
Acceptance date:
2014-01-01
DOI:
ISSN:
1476-1645 and 0002-9637
Pmid:
24591439


Language:
English
Keywords:
Pubs id:
pubs:451115
UUID:
uuid:f1dfd360-cc48-4549-887a-a4ff6ee24218
Local pid:
pubs:451115
Deposit date:
2016-09-24

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