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Non-viral gene delivery in skeletal muscle: a protein factory.

Abstract:

Ever since the publication of the first reports in 1990 using skeletal muscle as a direct target for expressing foreign transgenes, an avalanche of papers has identified a variety of proteins that can be synthesized and correctly processed by skeletal muscle. The impetus to the development of such applications is not only amelioration of muscle diseases, but also a range of therapeutic applications, from immunization to delivery of therapeutic proteins, such as clotting factors and hormones. ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301874

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Partridge, TA More by this author
Journal:
Gene therapy
Volume:
10
Issue:
2
Pages:
131-142
Publication date:
2003-01-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:f1d72bf1-acd6-4d5d-916f-9f99a6c395b7
Source identifiers:
223484
Local pid:
pubs:223484

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