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Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.

Abstract:

AIM: The Wnt/β-catenin signaling network offers potential targets to diagnose and uncouple obesity from its metabolic complications. In this study, we investigate the role of the Wnt antagonist, secreted frizzled-related protein 1 (SFRP1), in promoting adipogenesis in vitro and adipose tissue expansion in vivo. METHODS: We use a combination of human and murine, in vivo and in vitro models of adipogenesis, adipose tissue expansion and obesity-related metabolic syndrome to profile the involveme...

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Publication status:
Published

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Publisher copy:
10.1038/ijo.2010.107

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
International journal of obesity (2005)
Volume:
34
Issue:
12
Pages:
1695-1705
Publication date:
2010-12-05
DOI:
EISSN:
1476-5497
ISSN:
0307-0565
URN:
uuid:f1d59068-cc9a-405c-94da-64b2e36c893e
Source identifiers:
149980
Local pid:
pubs:149980

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