Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements. A PET study.

Journal article

Patients with Parkinson's disease have great difficulty in performing sequential and bimanual movements. We used H2(15)O PET to study the regional cerebral blood flow associated with performance of sequential finger movements made unimanually and bimanually in a group of Parkinson's disease patients and a group of control volunteers. In controls, sequential finger movements led to activation of the contralateral motor cortex and inferior parietal cortex (Brodmann area 40), the lateral premoto...

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Authors: Samuel, M; Ceballos-Baumann, A; Blin, J; Uema, T; Boecker, H

• Publication status: Published
• Journal: Brain : a journal of neurology
• Volume: 120 ( Pt 6)
• Issue: 6
• Pages: 963-976
• Publication date: 1997-06-01
• DOI: 10.1093/brain/120.6.963
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Evoked Potentials, Motor; Tomography, Emission-Computed; Corpus Striatum; Motor Cortex; Male; Psychomotor Performance; Parietal Lobe; Humans; Parkinson Disease; Movement; Reaction Time; Aged; Frontal Lobe; Female