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Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis.

Abstract:

Melioidosis is a severe infection caused by the flagellated bacterium Burkholderia pseudomallei. The nonsense polymorphism TLR51174C>T is associated with improved outcome in Thais with melioidosis. We hypothesized that other TLR5 variants may modulate the host response and determine outcome in melioidosis. We genotyped 12 TLR5 variants selected de novo from the HapMap database and examined the association of each with cytokines induced by flagellin stimulation of whole blood from healthy T...

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Publication status:
Published

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Publisher copy:
10.1038/gene.2013.60

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
Nature Publishing Group
Journal:
Genes and immunity More from this journal
Volume:
15
Issue:
2
Pages:
63-71
Publication date:
2014-03-01
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
Language:
English
Keywords:
Pubs id:
pubs:440352
UUID:
uuid:f1ca9786-b09b-47d0-bfc9-11d362e58755
Local pid:
pubs:440352
Source identifiers:
440352
Deposit date:
2014-07-17

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