Journal article
Correctors of mutant CFTR enhance subcortical cAMP/PKA signaling via ezrin phosphorylation and cytoskeleton organization
- Abstract:
-
The most common mutation of Cystic Fibrosis (CF) Transmembrane Regulator (CFTR) gene, F508del, produces a misfolded protein resulting in its defective trafficking to the cell surface and an impaired chloride secretion. Pharmacological treatments partially rescue F508del CFTR activity either directly by interacting with the mutant protein and/or indirectly by altering the cellular protein homeostasis. We show that the ezrin phosphorylation together with its binding to phosphatidylinositol-4,5-...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Zaccolo, M
Grant:
PG/15/5/31110
RG/12/3/29423
Bibliographic Details
- Publisher:
- Company of Biologists Ltd Publisher's website
- Journal:
- Journal of Cell Science Journal website
- Publication date:
- 2016-01-01
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- Source identifiers:
-
599424
Item Description
- Keywords:
- Pubs id:
-
pubs:599424
- UUID:
-
uuid:f1c08030-d035-415e-8f22-5f2a258357c0
- Local pid:
- pubs:599424
- Deposit date:
- 2016-02-08
Terms of use
- Copyright holder:
- Abbattiscianni et al
- Copyright date:
- 2016
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