High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae.

Journal article

Non-typeable (NT) or capsule-deficient, Haemophilus influenzae (Hi) is a common commensal of the upper respiratory tract of humans and can be pathogenic resulting in diseases such as otitis media, sinusitis and pneumonia. The lipopolysaccharide (LPS) of NTHi is a major virulence factor that displays substantial intra-strain and inter-strain variation of its oligosaccharide structures. To investigate the genetic basis of LPS variation we sequenced internal regions of each of seven genes requir...

Expand abstract

Authors: Cody, A; Field, D; Feil, E; Stringer, S; Deadman, M

• Publication status: Published
• Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
• Volume: 3
• Issue: 1
• Pages: 57-66
• Publication date: 2003-05-01
• DOI: 10.1016/s1567-1348(02)00152-1
• EISSN: 1567-7257
• ISSN: 1567-1348
• Language: English
• Keywords: Polymorphism, Genetic; Molecular Sequence Data; Haemophilus influenzae; Haemophilus Infections; Virulence; Genetic Variation; Genetic Linkage; Recombination, Genetic; Lipopolysaccharides; Genes, Bacterial; Humans; Respiratory Tract Infections; Phylogeny; Molecular Structure; Otitis Media