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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Abstract:

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in...

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Publication status:
Published

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Publisher copy:
10.1021/jm040072r

Authors


Freeman, GA More by this author
Andrews Iii, CW More by this author
Hopkins, AL More by this author
Lowell, GS More by this author
Schaller, LT More by this author
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Journal:
Journal of medicinal chemistry
Volume:
47
Issue:
24
Pages:
5923-5936
Publication date:
2004-11-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:f1bb33ca-dc06-4a02-98a5-bab86148011b
Source identifiers:
17337
Local pid:
pubs:17337

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