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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Abstract:

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in...

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Publication status:
Published

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Publisher copy:
10.1021/jm040072r

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Journal:
Journal of medicinal chemistry
Volume:
47
Issue:
24
Pages:
5923-5936
Publication date:
2004-11-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:f1bb33ca-dc06-4a02-98a5-bab86148011b
Source identifiers:
17337
Local pid:
pubs:17337

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