A quantitative description of components of in vitro morphometric change in the rat osteoclast model: relationships with cellular function.

Journal article

We describe the in vitro morphometric changes shown by rat osteoclasts that accompany their functional responses to the application of a range of regulatory agents of known physiological importance. We introduce a cellular motility parameter, mu, which was defined through a quantification of retraction-protrusion behaviour. This was used in conjunction with a net cell retraction, rho, which is derived from the change in total cell area following the application of an agent. These terms were u...

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Authors: Zaidi, M; Alam, A; Shankar, V; Bax, B; Moonga, B

• Publisher: Springer-Verlag
• Journal: European biophysics journal : EBJ
• Volume: 21
• Issue: 5
• Pages: 349-355
• Publication date: 1992-01-01
• DOI: 10.1007/bf00188348
• EISSN: 1432-1017
• ISSN: 0175-7571
• Language: English
• Keywords: Kinetics; Amyloid; Cells, Cultured; Models, Structural; Animals; Islet Amyloid Polypeptide; Rats; Time Factors; Osteoclasts; Rats, Wistar; Calcitonin; Cell Movement; Animals, Newborn; Calcium