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Combination of novel agents with radiotherapy to treat rectal cancer

Abstract:

Neoadjuvant chemoradiotherapy with fluoropyrimidines is an established treatment in the management of locally advanced rectal cancer. There has been a great deal of research into improving patient outcomes by modifying this regimen by the addition of further radiosensitising agents. One of the difficulties in advancing new combination therapies has been lack of consensus on which surrogate measures best reflect clinically important outcomes. Here we review combinations of the cytotoxic, biolo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.clon.2015.11.002

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Publisher:
WB Saunders Publisher's website
Journal:
Clinical Oncology Journal website
Volume:
28
Issue:
2
Pages:
116-139
Publication date:
2015-12-21
DOI:
ISSN:
1433-2981
URN:
uuid:f1a37a52-d56e-4422-8eac-45a44132a0e6
Source identifiers:
581155
Local pid:
pubs:581155

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