Ruthenium half-sandwich complexes bound to protein kinase Pim-1.

Journal article

(Figure Presented) Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.

Authors: Debreczeni, J; Bullock, A; Atilla, G; Williams, D; Bregman, H

• Publication status: Published
• Journal: Angewandte Chemie (International ed. in English)
• Volume: 45
• Issue: 10
• Pages: 1580-1585
• Publication date: 2006-02-01
• DOI: 10.1002/anie.200503468
• EISSN: 1521-3773
• ISSN: 1433-7851
• Language: English
• Keywords: Stereoisomerism; Crystallography, X-Ray; Protein Kinase Inhibitors; Models, Molecular; Ruthenium; Proto-Oncogene Proteins c-pim-1; Protein Structure, Tertiary