Journal article

Native functionality and therapeutic targeting of arenaviral glycoproteins

Abstract:: Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralising antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response and immunoglobulin-based therapeutics. Arenaviral glycoprotein-mediated assembly and infection pathways present numerous opportunities and challenges for therapeutic intervention.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Crispin, M., Zeltina, A., Zitzmann, N., & Bowden, T. (2016). Native functionality and therapeutic targeting of arenaviral glycoproteins. Current Opinion in Virology, 18, 70–75.

MLA Style

Crispin, M., et al. “Native Functionality and Therapeutic Targeting of Arenaviral Glycoproteins.” Current Opinion in Virology, vol. 18, Elsevier, 2016, pp. 70–75.

Chicago Style

Crispin, M, A Zeltina, N Zitzmann, and T Bowden. 2016. “Native Functionality and Therapeutic Targeting of Arenaviral Glycoproteins.” Current Opinion in Virology 18: 70–75.
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Files:: Native functionality and therapeutic targeting of arenaviral g...

(Preview, Version of record, pdf, 772.3KB, Terms of use)

Publisher copy:: 10.1016/j.coviro.2016.04.001

Authors

+ Crispin, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Role:: Author

+ Zeltina, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Biology
Role:: Author

+ Zitzmann, N More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Role:: Author

+ Bowden, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Biology
Role:: Author

+ Medical Research Council More from this funder

Funding agency for:: Bowden, T
Grant:: MR/J007897/1; MR/N002091/1

+ Unither Virology More from this funder

Funding agency for:: Zitzmann, N
Grant:: Personal consultancy

+ Marie Curie Fellowship More from this funder

Funding agency for:: Zeltina, A
Grant:: 658363

+ Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery Grant More from this funder

Funding agency for:: Crispin, M
Grant:: UM1AI100663

Publisher:: Elsevier
Journal:: Current Opinion in Virology More from this journal
Volume:: 18
Pages:: 70–75
Publication date:: 2016-04-16
Acceptance date:: 2016-04-04
DOI:: 10.1016/j.coviro.2016.04.001
EISSN:: 1879-6265
ISSN:: 1879-6257

Keywords:: glycoprotein

Arenavirus

vaccine

antivirals

structure
Pubs id:: pubs:613759
UUID:: uuid:f19c2fab-ea7e-494d-ae87-507edd69ca9b
Local pid:: pubs:613759
Source identifiers:: 613759
Deposit date:: 2016-04-05

Terms of use

Copyright holder:: Crispin et al
Copyright date:: 2016
Notes:: Copyright © 2016 The Authors. Published by Elsevier B.V. This is an
open access article under the CC BY license (http://creativecommons.
org/licenses/by/4.0/).

Licence:: CC Attribution (CC BY)

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