Journal article
Vitamin D, bone mineral density and risk of fracture in patients with intellectual disabilities
- Abstract:
-
Background People with intellectual disabilities (ID) have very high osteoporosis and fractures rates, to which their widespread vitamin D deficiency and other factors could contribute. We aimed to assess in ID people previously treated for vitamin D deficiency 1) long-term adherence to vitamin D supplementation and 2) bone mineral density (BMD), as an indicator for risk of fractures, according to vitamin D supplementation and other factors.
Method Height, weight, medical, pharmacological, dietary and lifestyle assessment; blood sample for vitamin D and related analytes; Dual-energy X-ray Absorptiometry (DXA) for BMD.
Results Of 51 study participants (mean [SD] age 51.5 [13.6] years, 57 % male), 41 (80.4%) were taking vitamin D and 10 were not. Mean [SD] serum vitamin D was 81.3 [21.3] vs 25.2 [10.2] nmol/L (p<0.0001) respectively. Thirty-six participants underwent a DXA scan, which showed osteoporosis in 23.7% and osteopenia in 52.6%. Participants on vitamin D had higher BMD than those who were not, a statistically significant difference when confounders (lack of mobility, hypogonadism) were removed. BMD was significantly different according to mobility, particularly in wheelchair users, in whom hip BMD was 33% lower (p<0.0001) than in participants with normal mobility. Participants still taking vitamin D showed a 6.1% increase in BMD at the spine (p=0.003) after mean [SD] 7.4 [1.5] years vitamin D treatment.
Conclusions In people with intellectual disabilities and previous vitamin D deficiency, bone mineral density increases on long-term vitamin D supplementation. However, additional strategies must be considered for osteoporosis and fracture prevention in this population.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 485.6KB, Terms of use)
-
- Publisher copy:
- 10.1111/jir.12581
Authors
Contributors
+ MENCAP
- Role:
- MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd
- Publisher:
- Wiley
- Journal:
- Journal of Intellectual Disability Research More from this journal
- Volume:
- 63
- Issue:
- 4
- Pages:
- 357-367
- Publication date:
- 2018-12-19
- Acceptance date:
- 2018-11-16
- DOI:
- EISSN:
-
1365-2788
- ISSN:
-
0964-2633
- Keywords:
- Pubs id:
-
pubs:946734
- UUID:
-
uuid:f196bb28-2bcf-4070-9b55-f18f8ab034ad
- Local pid:
-
pubs:946734
- Source identifiers:
-
946734
- Deposit date:
-
2018-11-28
- ARK identifier:
Terms of use
- Copyright date:
- 2018
- Notes:
- © 2018 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/jir.12581
If you are the owner of this record, you can report an update to it here: Report update to this record