Journal article

Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.

Abstract:: The discovery of (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides and their binding affinities for a selection of 5-HT and dopamine subreceptors is described. Many compounds show high affinity (pK(i)>8) for the 5-HT(6) receptor and >100-fold selectivity against a range of other receptors. Structure-activity relationships of these compounds are discussed.

Publication status:: Published

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APA Style

Bromidge, S., Griffith, K., Heightman, T., Jennings, A., King, F., Moss, S., Newman, H., Riley, G., Routledge, C., Serafinowska, H., & Thomas, D. R. (2001). Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor. Bioorganic and Medicinal Chemistry Letters, 11(21), 2843–2846.

MLA Style

Bromidge, S., et al. “Novel (4-Piperazin-1-Ylquinolin-6-Yl) Arylsulfonamides with High Affinity and Selectivity for the 5-HT(6) Receptor.” Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 21, 2001, pp. 2843–46.

Chicago Style

Bromidge, S, K Griffith, T Heightman, A Jennings, F King, S Moss, H Newman, et al. 2001. “Novel (4-Piperazin-1-Ylquinolin-6-Yl) Arylsulfonamides with High Affinity and Selectivity for the 5-HT(6) Receptor.” Bioorganic and Medicinal Chemistry Letters 11 (21): 2843–46.
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Publisher copy:: 10.1016/s0960-894x(01)00558-3

Authors

+ Bromidge, S More by this author

Role:: Author

+ Griffith, K More by this author

Role:: Author

+ Heightman, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Genomics Consortium
Role:: Author

+ Jennings, A More by this author

Role:: Author

+ King, F More by this author

Role:: Author

More authors...

Journal:: Bioorganic and medicinal chemistry letters More from this journal
Volume:: 11
Issue:: 21
Pages:: 2843-2846
Publication date:: 2001-11-01
DOI:: 10.1016/s0960-894x(01)00558-3
EISSN:: 1464-3405
ISSN:: 0960-894X

Language:: English
Keywords:: Serotonin Antagonists

Receptors, Dopamine

Sulfonamides

Receptors, Serotonin

Molecular Structure
Pubs id:: pubs:31963
UUID:: uuid:f191eb04-da15-4150-ad1a-f9d881000d0b
Local pid:: pubs:31963
Source identifiers:: 31963
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2001

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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