Angiogenesis in endocrine tumors.

Journal article

Angiogenesis is the process of new blood vessel development from preexisting vasculature. Although vascular endothelium is usually quiescent in the adult, active angiogenesis has been shown to be an important process for new vessel formation, tumor growth, progression, and spread. The angiogenic phenotype depends on the balance of proangiogenic growth factors such as vascular endothelial growth factor (VEGF) and inhibitors, as well as interactions with the extracellular matrix, allowing for e...

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Authors: Turner, H; Harris, A; Melmed, S; Wass, J

• Publication status: Published
• Journal: Endocrine reviews
• Volume: 24
• Issue: 5
• Pages: 600-632
• Publication date: 2003-10-01
• DOI: 10.1210/er.2002-0008
• EISSN: 1945-7189
• ISSN: 0163-769X
• Language: English
• Keywords: Neuroendocrine Tumors; Neovascularization, Pathologic; Adrenal Gland Neoplasms; Parathyroid Neoplasms; Humans; Pituitary Neoplasms; Vascular Endothelial Growth Factor A; Matrix Metalloproteinases; Animals; Endocrine Gland Neoplasms; Thyroid Neoplasms; Gastrointestinal Neoplasms; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Carcinoid Tumor