A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

Journal article

The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking...

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Authors: Sluss, H; Han, Z; Barrett, T; Goberdhan, D; Wilson, C

• Journal: Genes and development
• Volume: 10
• Issue: 21
• Pages: 2745-2758
• Publication date: 1996-11-01
• DOI: 10.1101/gad.10.21.2745
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Amino Acid Sequence; Mitogen-Activated Protein Kinase Kinases; Base Sequence; Drosophila; DNA, Complementary; Sequence Homology, Amino Acid; Phosphorylation; Morphogenesis; Animals; Gene Expression Regulation, Enzymologic; Alleles; Signal Transduction; Phenotype; Protein Kinases; Substrate Specificity; Molecular Sequence Data; Drosophila Proteins; Gene Expression Regulation, Developmental