Journal article
Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.
- Abstract:
-
CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotransplantation. The amino-terminal ligand binding domain of SIRPα is highly polymorphic in contrast to the single Ig-like domain of CD47. There is confusion as to whether the polymorphisms will affect ligand binding...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m114.550558
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Inc.
- Journal:
- Journal of biological chemistry
- Volume:
- 289
- Issue:
- 14
- Pages:
- 10024-10028
- Publication date:
- 2014-04-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
449052
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:449052
- UUID:
-
uuid:f15fea43-0c7e-429f-a9c3-3fc0644e3d6c
- Local pid:
- pubs:449052
- Deposit date:
- 2014-02-24
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- Copyright date:
- 2014
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