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Journal article

Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.

Abstract:

CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotransplantation. The amino-terminal ligand binding domain of SIRPα is highly polymorphic in contrast to the single Ig-like domain of CD47. There is confusion as to whether the polymorphisms will affect ligand binding...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m114.550558

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
The Journal of biological chemistry
Volume:
289
Issue:
14
Pages:
10024-10028
Publication date:
2014-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:f15fea43-0c7e-429f-a9c3-3fc0644e3d6c
Source identifiers:
449052
Local pid:
pubs:449052

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