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The dependence of the association rate of surface-attached adhesion molecules CD2 and CD48 on separation distance.

Abstract:

The kinetics of bond formation between spherical beads coated with CD48 and CD2-derivatized surfaces was studied with a flow chamber. For a given shear rate, the binding frequency was exquisitively sensitive to the particle velocity. Flow equations were used to derive the particle-to-surface distance from the velocity, thus yielding a relationship between this distance and the binding rate. Numerical values of the binding site densities allowed absolute determination of the rate of associatio...

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Authors


Pierres, A More by this author
Benoliel, AM More by this author
Bongrand, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
FEBS letters
Volume:
403
Issue:
3
Pages:
239-244
Publication date:
1997-02-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:f1543b5d-709f-49d2-ac6a-ba45268699d9
Source identifiers:
10830
Local pid:
pubs:10830

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