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Journal article

Development of molecular agents for IGF receptor targeting.

Abstract:

The type 1 insulin-like growth factor receptor (IGF1R) is a promising anticancer treatment target, being frequently overexpressed by tumours, and mediating proliferation, motility and apoptosis protection. Design of specific kinase inhibitors is problematic because of homology between the IGF1R and insulin receptor. This obstacle can be circumvented using sequence-specific molecular agents including antisense, triplex and ribozymes. Recent studies indicate that profound sequence-specific IGF1...

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Publication status:
Published

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Publisher copy:
10.1055/s-2004-814158

Authors


Journal:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Volume:
35
Issue:
11-12
Pages:
843-849
Publication date:
2003-01-01
DOI:
EISSN:
1439-4286
ISSN:
0018-5043
URN:
uuid:f1505c00-ad13-4e8e-858b-03c40ce2907d
Source identifiers:
315955
Local pid:
pubs:315955

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