Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Journal article

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Authors: Yeager, M; Chatterjee, N; Ciampa, J; Jacobs, K; Gonzalez-Bosquet, J

• Publication status: Published
• Journal: Nature genetics
• Volume: 41
• Issue: 10
• Pages: 1055-1057
• Publication date: 2009-10-01
• DOI: 10.1038/ng.444
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Genetic Markers; Disease Susceptibility; Genome, Human; Prostatic Neoplasms; Polymorphism, Single Nucleotide; Chromosomes, Human, Pair 8; Male; Genome-Wide Association Study; European Continental Ancestry Group; Genotype; Risk Factors; Humans