Interleukin-18: perspectives on the newest interleukin.

Journal article

Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.

Authors: Gillespie, M; Horwood, N

• Journal: Cytokine and growth factor reviews
• Volume: 9
• Issue: 2
• Pages: 109-116
• Publication date: 1998-06-01
• DOI: 10.1016/s1359-6101(98)00004-5
• EISSN: 1879-0305
• ISSN: 1359-6101
• Language: English
• Keywords: Humans; Animals; Neoplasms, Experimental; T-Lymphocytes; Molecular Sequence Data; Receptors, Interleukin-18; Osteoclasts; Gene Expression; Interleukin-18 Receptor alpha Subunit; Amino Acid Sequence; Interleukin-18; Autoimmunity; Diabetes Mellitus, Type 1; Interleukin-1; Receptors, Interleukin