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Cognitive performance in neurokinin 3 receptor knockout mice.

Abstract:

RATIONALE: The neurokinin 3 (NK(3)) receptor is a novel target under investigation for improvement of the symptoms of schizophrenia due to its ability to modulate dopaminergic signaling. However, research on effects of NK(3) antagonism with animal models has been hindered because of species differences in the receptor between humans, rats, and mice. OBJECTIVES: The aim of the present study is to further knowledge on the role of NK(3) in cognitive functioning by testing the effect of knockout...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-008-1119-6

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Psychopharmacology
Volume:
198
Issue:
2
Pages:
211-220
Publication date:
2008-06-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:f131394f-7aa1-46c3-a871-d05b32da2851
Source identifiers:
186232
Local pid:
pubs:186232

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