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Journal article

Proteasome inhibitors as anti-cancer agents.

Abstract:

The ubiquitin (Ub)-proteasome pathway is the major nonlysosomal pathway of proteolysis in human cells and accounts for the degradation of most short-lived, misfolded or damaged proteins. This pathway is important in the regulation of a number of key biological regulatory mechanisms. Proteins are usually targeted for proteasome-mediated degradation by polyubiquitinylation, the covalent addition of multiple units of the 76 amino acid protein Ub, which are ligated to 1-amino groups of lysine res...

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Publication status:
Published

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Journal:
Anti-cancer drugs
Volume:
11
Issue:
6
Pages:
407-417
Publication date:
2000-07-05
DOI:
EISSN:
1473-5741
ISSN:
0959-4973
URN:
uuid:f1307cb8-d9b5-48c5-9b7d-e871ed6d179e
Source identifiers:
20355
Local pid:
pubs:20355

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