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Journal article

Potentiation of TNF-alpha toxicity by conjugation with ricin A-chain.

Abstract:

Hybrid toxins containing a cytokine moiety have been used effectively to selectively kill cells expressing the complementary cytokine receptor both in vivo and in vitro. To date all cytokines incorporated into hybrid toxins, e.g. interleukin 2 are biologically active as monomers, so attachment of a toxin group causes minimal interference with the cytokine structure. By contrast, the pro-inflammatory and anti-cancer cytokine tumour necrosis factor alpha (TNF-alpha) is biologically active as a ...

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Publication status:
Published

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Publisher copy:
10.1006/cyto.1998.0395

Authors


Foxwell, BM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Chernajovsky, Y More by this author
Journal:
Cytokine
Volume:
10
Issue:
12
Pages:
931-939
Publication date:
1998-12-05
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
URN:
uuid:f12efbc0-2b01-4e49-ac4b-fa19d313ece2
Source identifiers:
481585
Local pid:
pubs:481585

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