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Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E.

Abstract:

Salmonella enterica serovar Typhi (S. typhi) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis, which is associated with the release of haemolysin E in membrane vesicles. This effect is attributed to increased expression of the small RNA micA and RNA chaperone Hfq, with concomitant downregulation of outer membrane protein A. Deletion of micA or the two-component signal-transduction system, CpxAR, abolishes the phenotype. The hormon...

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Publication status:
Published

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Publisher copy:
10.1038/embor.2011.4

Authors


Karavolos, MH More by this author
Bulmer, DM More by this author
Spencer, H More by this author
Rampioni, G More by this author
Schmalen, I More by this author
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Journal:
EMBO reports
Volume:
12
Issue:
3
Pages:
252-258
Publication date:
2011-03-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:f12620e6-8ac6-4806-9d04-32b98243d1e5
Source identifiers:
120554
Local pid:
pubs:120554

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