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Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

Abstract:
The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins.
Publication status:
Published

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Publisher copy:
10.1021/ol402638n

Authors


Pullin, RD More by this author
Melikhova, EY More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
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Journal:
Organic letters
Volume:
15
Issue:
21
Pages:
5492-5495
Publication date:
2013-11-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:f125db59-e57e-402c-928f-1501e40a41c5
Source identifiers:
434340
Local pid:
pubs:434340

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