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Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB(4) dendritic building block: rapid synthesis of a second generation dendrimer

Abstract:
Bis(1,3-dihydroxy-isopropyl)amine (BDI)1, a symmetrical AB4 dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate. Branch cells of this rare multiplicity allow the rapid construction of a second generation dendrimer 5 with 48 protected peripheral primary alcohol groups. (C) 2000 Elsevier Science Ltd.
Publication status:
Published

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Publisher copy:
10.1016/S0040-4039(00)00487-1

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
41
Issue:
20
Pages:
3959-3962
Publication date:
2000-05-21
DOI:
ISSN:
0040-4039


Language:
English
Pubs id:
pubs:37384
UUID:
uuid:f11b8bf7-902d-4360-9616-bcf5ff55477d
Local pid:
pubs:37384
Source identifiers:
37384
Deposit date:
2012-12-19

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