Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.

Journal article

Rolipram is a type IV phosphodiesterase inhibitor that suppresses inflammation and TNF-alpha production. As anti-TNF-alpha therapy is effective in rheumatoid arthritis, we investigated the effect of rolipram on collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis. Rolipram was administered after the onset of clinical arthritis at doses of 0.5, 3, 5, or 10 mg/kg twice daily, with a dose-dependent therapeutic effect on clinical severity and joint erosion. Immunohistochemical...

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Authors: Ross, SE; Williams, R; Mason, L; Mauri, C; Marinova-Mutafchieva, L

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 159
• Issue: 12
• Pages: 6253-6259
• Publication date: 1997-12-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Th1 Cells; Antigens, CD4; Animals; Pyrrolidinones; Antibodies, Monoclonal; Cytokines; Male; Interleukin-12; Mice; Immunosuppressive Agents; Cattle; Mice, Inbred DBA; Tumor Necrosis Factor-alpha; Collagen; Down-Regulation; Drug Therapy, Combination; Rolipram; Anti-Inflammatory Agents, Non-Steroidal; Arthritis