Journal article
Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
- Abstract:
- Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 286.4KB, Terms of use)
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- Publisher copy:
- 10.1097/qad.0b013e328314b5df
Authors
- Publisher:
- Lippincott Williams and Wilkins
- Journal:
- AIDS More from this journal
- Volume:
- 22
- Issue:
- 16
- Pages:
- 2214-2217
- Publication date:
- 2008-10-01
- DOI:
- EISSN:
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1473-5571
- ISSN:
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0269-9370
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:100136
- UUID:
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uuid:f1159cce-5dcc-4124-be8a-2e77e86e9600
- Local pid:
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pubs:100136
- Source identifiers:
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100136
- Deposit date:
-
2012-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Lippincott, Williams and Wilkins
- Copyright date:
- 2008
- Notes:
- Copyright © Lippincott, Williams and Wilkins. Published by Lippincott, Williams and Wilkins on behalf of the International AIDS Society. This is the publisher's version of the article. The final version is available online from Lippincott, Williams and Wilkins at: [10.1097/qad.0b013e328314b5df]
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