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Journal article

Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.

Abstract:

Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1097/qad.0b013e328314b5df

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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International AIDS Vaccine Initiative More from this funder
Wellcome Trust More from this funder
Oxford Glycobiology Endowment More from this funder
Publisher:
Lippincott Williams and Wilkins Publisher's website
Journal:
AIDS Journal website
Volume:
22
Issue:
16
Pages:
2214-2217
Publication date:
2008-10-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:f1159cce-5dcc-4124-be8a-2e77e86e9600
Source identifiers:
100136
Local pid:
pubs:100136

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