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Molecular model of a type III secretion system needle: Implications for host-cell sensing.

Abstract:

Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens. The type III secretion system consists of cytoplasmic, transmembrane, and extracellular domains. The extracellular domain is a hollow needle protruding above the bacterial surface and is held within a basal body that traverses both bacterial membranes. Effector proteins are translocated, via this external needle, directly into host cells, where they subvert normal cell functions to aid ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0602689103

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
103
Issue:
33
Pages:
12529-12533
Publication date:
2006-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f112ca37-6fdd-4e33-9f54-cf22354cecf7
Source identifiers:
20454
Local pid:
pubs:20454

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