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A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

Abstract:

Drosophila has three membrane-tethered epidermal growth factor (EGF)-like proteins: Spitz, Gurken and Keren. Spitz and Gurken have been genetically confirmed to activate the EGF receptor, but Keren is uncharacterized. Spitz is activated by regulated intracellular translocation and cleavage by the transmembrane proteins Star and the protease Rhomboid-1, respectively. Rhomboid-1 is a member of a family of seven similar proteins in Drosophila. We have analysed four of these: all are proteases th...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/cdf434

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
EMBO journal
Volume:
21
Issue:
16
Pages:
4277-4286
Publication date:
2002-08-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
356084

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