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Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.

Abstract:

Metastasis results from a sequence of selective events often involving interactions with elements of the tumor-specific physiological microenvironment. The low-serum component of this microenvironment confers increased motility and invasion in breast cancer cells by activating the Na+/H+ exchanger isoform 1 (NHE1). The present study was undertaken to characterize the signal transduction mechanisms underlying this serum deprivation-dependent activation of both the NHE1 and the concomitant inva...

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Publisher copy:
10.1091/mbc.e04-10-0945

Authors


Cardone, RA More by this author
Bagorda, A More by this author
Bellizzi, A More by this author
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Journal:
Molecular biology of the cell
Volume:
16
Issue:
7
Pages:
3117-3127
Publication date:
2005-07-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:f10c734d-6067-45b0-8de8-df8cc1825da7
Source identifiers:
237275
Local pid:
pubs:237275

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