Maximal response to a plasma cholesterol-lowering diet is achieved within two weeks.

Journal article

BACKGROUND AND AIM: Replacing saturated fat with polyunsaturated fat reduces plasma cholesterol concentrations; however, it has not been well documented how rapidly the decline occurs nor how long is required to reach the maximum cholesterol-lowering effect. The aim of the present study was to determine the time course of change in plasma cholesterol concentrations when participants adopt a lipid-lowering diet. METHODS AND RESULTS: Participants (n = 19) were asked to follow for 19 days a diet high in saturated fat and then crossed over--without washout--for 19 days to a diet high in n-6 polyunsaturated fat. Participants were asked to maintain a total fat intake of 30-33% of total energy on both diets. Energy and nutrient intakes were assessed by self-reported food records covering 3 days. Plasma total cholesterol concentrations were measured on days 0, 1, 2, 5, 8, 12, and 19 of the n-6 polyunsaturated fat rich diet. Mean (95% CI) plasma total cholesterol concentration declined from 5.10 mmol/L (4.77, 5.46) at day 0 to 4.25 mmol/L (3.83, 4.67) on day 12 and remained unchanged at 4.23 mmol/L (3.85, 4.61) on day 19. A statistically significant decrease in plasma cholesterol concentration was achieved on day 2 of the intervention; by day 5, 59% (0.51 mmol/L) of the maximum reduction (0.87 mmol/L) had been reached. CONCLUSIONS: Adopting a lipid lowering diet initiates an immediate decline in plasma cholesterol concentration, the full effect of which is achieved within two weeks.

Authors: Hodson, L; Skeaff, C; McKenzie, J

• Publication status: Published
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD
• Volume: 12
• Issue: 5
• Pages: 291-295
• Publication date: 2002-10-01
• EISSN: 1590-3729
• ISSN: 0939-4753
• Language: English
• Keywords: Cholesterol; Diet, Fat-Restricted; Female; Humans; Fatty Acids, Omega-6; Diet Records; Cross-Over Studies; Treatment Outcome; Fatty Acids, Unsaturated; Male; Hypercholesterolemia; Adult; Dietary Fats; Time Factors; Dietary Fats, Unsaturated